Lokelma Administration Instructions
Lokelma (sodium zirconium cyclosilicate) should be mixed with approximately 3 tablespoons (45 mL) of water. 1
Preparation and Administration
According to the FDA drug label, the powder should be:
- Emptied into a drinking glass containing approximately 3 tablespoons (45 mL) of water
- Stirred well to create a suspension
- Consumed immediately - the mixture should not be stored
- Additional water may be added to the glass after drinking to ensure the full dose is taken
Important Administration Details
Do not mix with food or other liquids - only water should be used. The medication is formulated specifically to be mixed with water to ensure proper suspension and absorption characteristics.
Timing considerations:
- Can be taken with or without food
- Should be separated from other oral medications by at least 2 hours (before or after) as Lokelma may bind other medications in the gastrointestinal tract
Dosing Context
The standard dosing regimen is:
- Initial correction phase: 10 g three times daily for up to 48 hours 2, 3
- Maintenance phase: 5-15 g once daily, titrated based on potassium levels 2, 3
Each 5 g dose contains approximately 400 mg of sodium, which is an important consideration for patients with heart failure, renal disease, or those on sodium-restricted diets. 1
Common pitfall to avoid: Do not use hot water or attempt to dissolve the powder completely - it is designed to remain as a suspension. The powder is insoluble and will not fully dissolve, which is the intended formulation.