From the Guidelines
Elevated histamine levels in your plasma (1.51) and a positive ANA test suggest possible immune system dysregulation, and I strongly recommend consulting with an immunologist or rheumatologist for proper evaluation and diagnosis. These findings could indicate several conditions including histamine intolerance, mast cell activation syndrome, or an autoimmune disorder. According to the most recent study 1, antihistamines may be used as adjunctive therapy for cutaneous signs and symptoms associated with anaphylaxis, but should not be administered before, or in place of, epinephrine.
Key Considerations
- Histamine levels can fluctuate due to various factors including stress, certain medications, and dietary intake 1
- A low-histamine diet may be beneficial in managing symptoms, avoiding fermented foods, aged cheeses, processed meats, and alcohol 1
- Antihistamines like loratadine 10mg daily or fexofenadine 180mg daily may be recommended to manage symptoms while awaiting further evaluation 1
- Additional testing such as specific autoantibody panels, complement levels, or tryptase measurements may be necessary to clarify the diagnosis 1
Next Steps
- Consult with an immunologist or rheumatologist for proper evaluation and diagnosis
- Keep a symptom diary to note any triggers like foods, stress, or environmental factors
- Consider a low-histamine diet and avoid potential triggers
- Follow up with a healthcare provider to discuss additional testing and treatment options
From the Research
Histamine Levels and Ana Test Results
- The Histamine, Plasma blood level is at 1.51, which may indicate an allergic reaction or histamine release in the body.
- A positive Ana test result suggests the presence of antinuclear antibodies, which can be associated with various autoimmune disorders.
- However, there is no direct correlation between histamine levels and Ana test results in the provided study 2.
Allergic Histamine Release
- The study 2 discusses the inhibition of allergic histamine release by azelastine and other antiallergic drugs from rabbit leukocytes.
- Azelastine is shown to be a potent inhibitor of allergic histamine secretion, with an IC50 level of 4.5 microM.
- The study suggests that azelastine can act rapidly on basophils and inhibit allergic histamine secretion, but it does not provide information on the relationship between histamine levels and Ana test results.
Relevance to Histamine Levels and Ana Test Results
- The provided study 2 does not directly address the question of why the Histamine, Plasma blood level is at 1.51 and the Ana test result is positive.
- Further research would be needed to understand the relationship between histamine levels, Ana test results, and the underlying causes of these test results.