Can Mucinex (Guaifenesin) be taken with Tessalon Perles (Benzonatate)?

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Last updated: May 22, 2025View editorial policy

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From the Research

It is generally safe to take Mucinex (guaifenesin) with Tessalon Perles (benzonatate) as they work differently to treat cough symptoms and don't have significant interactions with each other. Mucinex is an expectorant that thins mucus to help clear congestion, while Tessalon Perles is a non-narcotic cough suppressant that reduces the urge to cough by numbing stretch receptors in the lungs. These medications can complement each other - Mucinex helps clear mucus while Tessalon Perles reduces the cough reflex.

Key Points to Consider

  • The combination of Mucinex and Tessalon Perles may be effective for acute cough due to the common cold, as suggested by a study published in 2009 1.
  • Guaifenesin, the active ingredient in Mucinex, has a well-established and favorable safety and tolerability profile in adult and pediatric populations, as reported in a study published in 2017 2.
  • However, you should always follow the dosing instructions for each medication separately and not exceed recommended amounts.
  • If you have underlying health conditions like kidney disease, heart problems, or are taking other medications, consult your healthcare provider before combining these medications.
  • Also, be aware of potential side effects from either medication, such as drowsiness, dizziness, or stomach upset, which could be amplified when taking both together.

Important Considerations

  • A study published in 2019 3 reviewed the role of guaifenesin in the management of chronic mucus hypersecretion associated with stable chronic bronchitis, highlighting its potential benefits in improving mucus clearance.
  • Another study published in 2017 4 explored the efficacy and safety of guaifenesin for upper back, neck, and shoulder pain, suggesting its potential benefits in providing relief from acute muscle spasm and pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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