What travel vaccinations are required for an adult traveling to Brazil?

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Last updated: May 22, 2025View editorial policy

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From the Guidelines

For travel to Brazil, adults should ensure they are up-to-date on routine vaccinations and consider additional vaccinations such as Yellow Fever, Hepatitis A, Typhoid, and Hepatitis B, as well as malaria prophylaxis if traveling to high-risk areas, to minimize the risk of morbidity and mortality. When traveling to Brazil, it is essential to prioritize vaccinations that protect against diseases prevalent in the region. According to the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), Yellow Fever vaccination is strongly recommended for travel to certain areas of Brazil, particularly the Amazon region 1. Some key vaccinations and medications to consider include:

  • Yellow Fever vaccine, which is live, attenuated virus preparation made from the 17D yellow fever virus strain, and is considered one of the safest and most effective live virus vaccines ever developed 1
  • Hepatitis A and Typhoid vaccines to protect against potential food and water contamination
  • Hepatitis B vaccination for most travelers, especially those who might need medical care or have close contact with locals
  • Malaria prophylaxis, such as atovaquone-proguanil, doxycycline, or mefloquine, for travel to the Amazon region
  • Rabies vaccination for extended stays or those planning outdoor activities Additionally, travelers should take precautions against insect bites by using repellents containing DEET, wearing long sleeves and pants, and using bed nets in areas without air conditioning to prevent diseases such as Dengue fever. It is crucial to consult a travel medicine specialist 4-6 weeks before departure for personalized recommendations based on your specific itinerary, health status, and planned activities.

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Travel Immunizations for Brazil

When traveling to Brazil, it is essential to consider the necessary immunizations to prevent infectious diseases.

  • Dengue fever is a significant concern, as it is the world's most important viral hemorrhagic fever disease and is widespread in Brazil 2.
  • Other diseases such as yellow fever, Zika, and Chikungunya are also present in the region 3.
  • Malaria is another vector-borne disease that can be found in certain areas of Brazil, and co-infections with other diseases like dengue and Chikungunya can occur 4.
  • The Brazilian government recommends vaccination against yellow fever for travelers to certain areas of the country.
  • There is no specific vaccine available for dengue fever, but prevention measures such as insecticide-treated bed nets and insect repellents can help reduce the risk of transmission.
  • Vaccination against hepatitis A and typhoid fever may also be recommended for travelers to Brazil, especially if they plan to eat or drink outside of major restaurants and hotels.
  • It is crucial to consult a healthcare professional to determine the necessary immunizations and precautions for travel to Brazil, as the risk of disease can vary depending on the specific destination and time of year 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Dengue hemorrhagic fever and acute hepatitis: a case report.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2004

Research

Severe dengue and liver involvement: an overview and review of the literature.

Expert review of anti-infective therapy, 2020

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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