From the Research
GHK-Cu, a naturally occurring copper peptide, has been shown to have potential benefits for skin health, including improved wound healing, reduced inflammation, and enhanced antioxidant activity, as demonstrated in a study published in 2020 1. The peptide works by promoting collagen production, enhancing wound healing, reducing inflammation, and supporting antioxidant activity. These mechanisms contribute to its potential benefits for skin rejuvenation, including improved elasticity, reduced fine lines, and enhanced skin texture. Some key points to consider when using GHK-Cu include:
- Typical topical formulations contain 1-2% concentration and should be applied once or twice daily to clean skin.
- The compound can be incorporated into an existing skincare routine, typically applied after cleansing and before moisturizing.
- GHK-Cu has been shown to have anti-inflammatory and tissue remodeling properties, as well as prominent antioxidant and anti-inflammatory effects in in vitro and in vivo studies 1.
- Preliminary observations suggest GHK can partially reverse cognitive impairment in aging mice by targeting anti-inflammatory and epigenetic pathways 1. While generally considered safe for topical use, some users may experience mild irritation or redness. It is also worth noting that the delivery of GHK-Cu through the skin can be enhanced using microneedles, as demonstrated in a study published in 2015 2, which found that microneedle-mediated delivery of GHK-Cu increased its skin penetration and permeation. Overall, the evidence suggests that GHK-Cu has potential benefits for skin health and may be a useful addition to a skincare routine, and its use should be considered for patients with skin concerns, particularly those related to aging and wound healing, due to its potential to improve morbidity, mortality, and quality of life outcomes.