From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
The most popular compounded dermatology medications in the USA include tretinoin-niacinamide-hydroquinone combinations for hyperpigmentation, custom antibiotic-steroid mixtures like clindamycin with betamethasone for inflammatory conditions, and specialized acne formulations combining benzoyl peroxide, clindamycin, and tretinoin. These compounded medications are popular because they allow dermatologists to create personalized formulations with multiple active ingredients at specific concentrations tailored to individual patient needs, as noted in a study on topical treatments in dermatology 1. They can combine medications that aren't commercially available together, adjust concentrations to minimize side effects, and create formulations in bases appropriate for specific skin types. Some key benefits of compounded medications include:
- Reduction of systemic adverse effects
- Improved patient acceptance
- Few drug interactions
- Ease of dose determination
- Avoidance of first-pass metabolism
- Direct access to the target site, as discussed in a study on compounded topical analgesics for chronic pain 2. Compounded medications are particularly valuable for patients who don't respond to conventional treatments or have allergies to inactive ingredients in commercial products. The exact formulations vary widely based on prescriber preference, patient needs, and regional compounding pharmacy capabilities, highlighting the importance of personalized treatment approaches in dermatology, as mentioned in a study on compounding topicals in dermatology 3. Pain management compounds containing ketamine, gabapentin, and lidocaine are frequently prescribed for neuropathic skin conditions, and customized moisturizers with ceramides and hyaluronic acid are common for eczema and dry skin. While there are limited data on the safety and efficacy of compounded medications, as noted in a study on compounding topicals in dermatology 3, they remain a valuable treatment option for many patients. It's worth noting that older studies, such as one from 1991 on the use of a hydrocolloid occlusive dressing plus triamcinolone acetonide cream for palmo-plantar pustulosis 4, may not be directly relevant to current compounding practices, but still highlight the importance of tailored treatment approaches in dermatology. Similarly, a study from 2008 on clobetasol propionate 5 provides insight into the use of topical steroids, but is not directly applicable to the question of popular compounded dermatology medications. Overall, the use of compounded medications in dermatology offers a range of benefits and treatment options for patients, and is an area of ongoing research and development.