Differential Diagnosis for Hemoptysis, Hematuria, and Chronic Sinusitis
Single Most Likely Diagnosis
- Wegener's Granulomatosis (Granulomatosis with Polyangiitis): This autoimmune disorder is characterized by the triad of hemoptysis, hematuria, and chronic sinusitis, making it the most likely diagnosis. It involves inflammation of the blood vessels and can affect various organs, including the lungs, kidneys, and sinuses.
Other Likely Diagnoses
- Microscopic Polyangiitis: This condition is another type of vasculitis that can cause hemoptysis, hematuria, and chronic sinusitis. It is similar to Wegener's Granulomatosis but typically lacks granulomatous inflammation.
- Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis): This is a type of vasculitis that often presents with asthma, eosinophilia, and involvement of multiple organ systems, including the lungs, kidneys, and sinuses.
- Goodpasture's Syndrome: This rare autoimmune disorder is characterized by the presence of anti-GBM antibodies and can cause hemoptysis and hematuria. However, chronic sinusitis is not a typical feature.
Do Not Miss Diagnoses
- Lung Cancer with Metastasis: Although less likely, lung cancer can cause hemoptysis, and if it metastasizes to the kidneys, it could also cause hematuria. Chronic sinusitis could be unrelated or a separate condition.
- Tuberculosis: TB can cause hemoptysis and, in rare cases, hematuria if it involves the kidneys. Chronic sinusitis can be a separate condition or related to TB in rare instances.
- Sarcoidosis: This condition can cause granulomatous inflammation in various organs, including the lungs, kidneys, and sinuses, potentially leading to the symptoms described.
Rare Diagnoses
- Behçet's Disease: This rare condition is characterized by inflammation of the blood vessels and can cause a wide range of symptoms, including oral and genital ulcers, skin lesions, and eye inflammation. It can also involve the lungs, kidneys, and sinuses, but this is less common.
- Relapsing Polychondritis: This rare autoimmune disorder involves inflammation of cartilage and can affect various parts of the body, including the respiratory tract, ears, and eyes. It can cause chronic sinusitis and, in rare cases, hemoptysis and hematuria if other organs are involved.