From the Research
It is generally safe to take quetiapine and levetiracetam together, but you should always consult your doctor before combining medications. Quetiapine is an antipsychotic medication, while levetiracetam is an anticonvulsant used to treat epilepsy. These medications work on different systems in the body and don't typically interact in a harmful way. However, both can cause drowsiness, so taking them together may increase this side effect.
- The most recent study 1 from 2024, which evaluated the safety and efficacy of levetiracetam loading doses in adult patients with benzodiazepine-refractory status epilepticus, did not report any significant interactions between levetiracetam and other medications, including antipsychotics like quetiapine.
- Another study 2 from 2011, which reviewed the use of levetiracetam in epilepsy, noted that levetiracetam lacks cytochrome P450 isoenzyme-inducing potential and is not associated with clinically significant pharmacokinetic interactions with other drugs, including other anticonvulsants and antipsychotics.
- However, it's essential to consider the potential for increased drowsiness and other side effects when taking these medications together, as reported in a study 3 from 2022, which discussed levetiracetam-induced aggression and acute behavioral changes. Your doctor may need to adjust the dosages of either medication when used in combination. They will consider factors such as your specific medical conditions, other medications you're taking, and your individual response to these drugs.
- It's crucial to inform your healthcare provider about all medications you're taking, including over-the-counter drugs and supplements, to ensure there are no potential interactions or contraindications, as suggested by a study 4 from 2009, which discussed the role of levetiracetam in managing neurologic and psychiatric disorders. They can provide personalized advice based on your complete medical history and current health status.
- A study 5 from 2009, which reviewed the benefit of combination therapy in epilepsy with levetiracetam, noted that combination treatment with levetiracetam and other anticonvulsants provides additional therapeutic benefit, which may be relevant when considering combination therapy with quetiapine.