From the Research
It is generally considered safe to take Entyvio (vedolizumab) with tadalafil, but you should always consult with your healthcare provider before combining these medications. Entyvio is a biologic medication used to treat inflammatory bowel diseases like Crohn's disease and ulcerative colitis, while tadalafil (Cialis, Adcirca) is used for erectile dysfunction, benign prostatic hyperplasia, or pulmonary arterial hypertension. These medications work through different mechanisms in the body - Entyvio targets gut-specific inflammation by blocking certain white blood cells from entering inflamed gut tissue, while tadalafil works by relaxing blood vessels to increase blood flow.
Key Considerations
- There are no significant known drug interactions between these two medications that would cause concern, as noted in various studies 1, 2, 3.
- However, individual factors such as your specific health conditions, other medications you may be taking, and dosages can affect how these drugs interact in your body.
- A recent study from 2025 4 discussed the safety and efficacy of combination therapy with macitentan and tadalafil in patients with pulmonary arterial hypertension, but did not specifically address interactions with Entyvio.
- Another study from 2024 5 analyzed the risk of priapism associated with phosphodiesterase type 5 inhibitors, including tadalafil, but did not provide information on interactions with Entyvio.
Recommendations
- Your doctor or pharmacist can review your complete medication list and medical history to ensure these medications are appropriate for you to take together.
- It is essential to follow their guidance and monitoring to minimize potential risks and ensure the best possible outcome for your specific condition.