There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for terbinafine (PO), levetiracetam (PO) do not address this question.
From the Research
Contraindications of Oral Terbinafine with Keppra (Levetiracetam)
There are no direct studies on the contraindications of oral terbinafine with Keppra (levetiracetam). However, we can look at the potential interactions between the two drugs:
- Terbinafine is associated with only a few interactions with other drugs, which is why terbinafine can generally be used without problems in older and multimorbid patients 1.
- Levetiracetam is not associated with clinically significant pharmacokinetic interactions with other drugs, including other AEDs 2.
- However, terbinafine can interact with certain drug substances, including substances of the group of antidepressants/antipsychotics and some cardiovascular drugs 1.
- There is no evidence to suggest that terbinafine interacts with levetiracetam, but it is always best to monitor patients for potential side effects when combining medications.
Potential Interactions
Some potential interactions to consider when taking oral terbinafine with Keppra (levetiracetam) include:
- Monitoring for increased risk of side effects, such as behavioral adverse effects, which have been associated with levetiracetam 2.
- Monitoring for potential interactions with other medications that the patient is taking, such as antidepressants or cardiovascular drugs 1.
- Considering alternative treatments or adjusting the dosage of terbinafine or levetiracetam if necessary, based on the patient's individual response to the medications.
Lack of Direct Evidence
There are no research papers that directly address the contraindications of oral terbinafine with Keppra (levetiracetam) 2, 3, 1, 4, 5. Therefore, it is essential to rely on the known properties and interactions of each drug to make informed decisions about their combined use.