What is the cause of a swollen hand without trauma?

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Last updated: May 23, 2025View editorial policy

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Differential Diagnosis for Swollen Hand without Trauma

  • Single most likely diagnosis
    • Cellulitis: This is a common cause of swollen hand without trauma, often resulting from a bacterial infection that can spread from a small break in the skin.
  • Other Likely diagnoses
    • Insect bite or sting: Certain insect bites or stings can cause significant swelling in the affected area.
    • Allergic reaction: An allergic reaction to a substance can cause swelling, redness, and itching in the hand.
    • Infection of the hand (e.g., paronychia, felon): Infections of the skin or soft tissues of the hand can cause swelling, pain, and redness.
    • Gout: Although more commonly associated with the feet, gout can also affect the hands, causing swelling, pain, and redness.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Necrotizing fasciitis: A rare but life-threatening infection that can cause swelling, pain, and skin necrosis.
    • Compartment syndrome: A condition where increased pressure within the muscles of the hand can lead to nerve and muscle damage.
    • Sepsis: A systemic infection that can cause swelling, fever, and other systemic symptoms.
  • Rare diagnoses
    • Sarcoidosis: A rare autoimmune disorder that can cause swelling and inflammation in various parts of the body, including the hands.
    • Erythromelalgia: A rare disorder that causes burning pain, heat, and swelling in the hands and feet.
    • Complex regional pain syndrome (CRPS): A rare condition that causes chronic pain, swelling, and skin changes in the affected limb.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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