What is the relationship between celiac disease and the development of normoglycemic ketoacidosis, hypokalemia, and hypophosphatemia in a patient with diabetes mellitus (DM) and pre-renal failure, not taking Sodium-Glucose Cotransporter 2 (SGLT-2) inhibitors?

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From the Research

La relación entre la enfermedad celíaca, la diabetes mellitus y la cetoacidosis normoglicémica en esta paciente representa un escenario metabólico complejo que requiere un enfoque terapéutico integral para abordar la morbidad, la mortalidad y la calidad de vida. La paciente presenta una combinación de enfermedad celíaca, diabetes mellitus y cetoacidosis normoglicémica, lo que sugiere que la enfermedad celíaca puede estar contribuyendo a problemas de malabsorción, lo que a su vez puede empeorar el control glucémico en la diabetes y llevar a trastornos metabólicos. La cetoacidosis normoglicémica (DKA euglicémica) suele ocurrir con inhibidores de SGLT-2, pero como la paciente no está tomando estos medicamentos, su condición probablemente se deba a una mala condición nutricional debido a la enfermedad celíaca no tratada o mal controlada.

  • La hipocalemia y la hipofosfatemia persistentes, junto con la falla renal pre-renal, indican trastornos metabólicos graves y deshidratación.
  • El tratamiento debe centrarse en abordar todos los componentes: dieta estrictamente libre de gluten para la enfermedad celíaca, terapia con insulina para el manejo de la diabetes, resucitación fluida agresiva con reemplazo de electrolitos (particularmente potasio y fosfato) y apoyo nutricional.
  • La monitorización de la función renal es crucial, ya que la falla renal pre-renal puede mejorar con la hidratación adecuada, según se menciona en 1 y 2. El tratamiento debe ser personalizado y ajustado según la respuesta clínica y los resultados de laboratorio, con un enfoque en la restauración de la función renal, la corrección de los trastornos electrolíticos y la mejora de la condición nutricional, como se sugiere en 3.

References

Research

Diabetic ketoacidosis.

Nature reviews. Disease primers, 2020

Research

Management of Diabetic Ketoacidosis in Adults: A Narrative Review.

Saudi journal of medicine & medical sciences, 2020

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