What is the role of Levocloperastine in chronic liver disease?

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Last updated: February 21, 2025View editorial policy

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From the Guidelines

Levocloperastine has no established role in the management of chronic liver disease, and its use is not recommended based on the provided evidence. The guidelines for nutrition in chronic liver disease focus on the management of osteoporosis, vitamin deficiencies, and other nutritional aspects, but do not mention levocloperastine as a treatment option 1.

When considering the management of patients with chronic liver disease, it is essential to focus on established treatments, such as:

  • Assessing and managing osteoporosis, particularly in patients with cholestatic diseases or those at high risk of fractures 1
  • Supplementing with calcium and vitamin D to prevent bone loss 1
  • Monitoring and managing vitamin deficiencies, particularly fat-soluble vitamins like vitamin D 1
  • Avoiding excessive sodium intake and monitoring hyponatremia in patients with cirrhosis 1

In the absence of evidence supporting the use of levocloperastine in chronic liver disease, it is crucial to prioritize established treatments and management strategies to minimize morbidity, mortality, and improve quality of life for these patients.

From the Research

Role of Levocloperastine in Chronic Liver Disease

There are no research papers to assist in answering this question, as none of the provided studies directly investigate the role of Levocloperastine in chronic liver disease.

Available Information on Levocloperastine

  • Levocloperastine is mentioned in one study as an antitussive agent, effective in treating chronic nonproductive cough 2.
  • The study compared the efficacy of levocloperastine with standard antitussive agents and found it to have improved or comparable efficacy with a more rapid onset of action and better tolerability profile 2.

Information on Chronic Liver Disease

  • Chronic liver disease can alter the kinetics of drugs, and dosage adjustment is often necessary 3, 4.
  • The management of chronic liver disease involves various strategies, including treatment of underlying causes, prevention of progression, and management of complications 5, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Drug dosage recommendations in patients with chronic liver disease.

Revista espanola de enfermedades digestivas, 2012

Research

Managing diabetes and liver disease association.

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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