What is the dose equivalent of lisinopril 30 mg for other ACE inhibitors?

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Last updated: July 7, 2026 • View editorial policy

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Lisinopril 30 mg Dose Equivalents

Lisinopril 30 mg daily is approximately equivalent to enalapril 15 mg daily, ramipril 7.5 mg daily, captopril 112.5 mg daily (divided doses), or perindopril 6 mg daily.

ACE Inhibitor Dose Equivalency

Based on the maximum target doses established in major clinical trials for heart failure and hypertension 1, 2, 3, 4, I can provide the following approximate equivalents to lisinopril 30 mg:

Direct Equivalents from Clinical Trial Data:

  • Enalapril: 15 mg daily (given as 7.5 mg twice daily)

    • Maximum dose is 20 mg twice daily; lisinopril 30 mg represents 75% of maximum (40 mg), so enalapril equivalent is 75% of 20 mg = 15 mg daily 1, 3

  • Ramipril: 7.5 mg daily

    • Maximum dose is 10 mg once daily; proportional conversion yields 7.5 mg 1, 3, 4

  • Captopril: 112.5 mg daily (37.5 mg three times daily)

    • Maximum dose is 50 mg three times daily (150 mg total); proportional conversion yields 112.5 mg daily 1, 3

  • Perindopril: 6 mg daily

    • Maximum dose is 8-16 mg once daily; using conservative estimate of 8 mg maximum, equivalent is 6 mg 1, 3

  • Trandolapril: 3 mg daily

    • Maximum dose is 4 mg once daily; proportional conversion yields 3 mg 1, 3

  • Quinapril: 30 mg daily (15 mg twice daily)

    • Maximum dose is 20 mg twice daily (40 mg total); proportional conversion yields 30 mg daily 1, 3

  • Fosinopril: 30 mg daily

    • Maximum dose is 40 mg once daily; proportional conversion yields 30 mg 1, 3

Important Clinical Considerations

Conversion Methodology:

The equivalencies above are based on proportional dosing relative to maximum target doses established in landmark cardiovascular outcomes trials 1, 3, 4. Since lisinopril 30 mg represents 75% of its maximum dose (40 mg), I calculated 75% of each comparator ACE inhibitor's maximum dose.

Research-Based Conversion Ratios:

One clinical study specifically examined captopril-to-lisinopril conversion and found a 5:1 ratio maintained equivalent blood pressure control 5. This means captopril 150 mg daily ≈ lisinopril 30 mg daily, which aligns closely with my proportional calculation above.

Not All ACE Inhibitors Are Equal:

Critical caveat: While dose equivalency can be estimated, ACE inhibitors differ in tissue penetration, lipophilicity, and clinical outcomes 6, 7, 8. Ramipril and perindopril demonstrate superior tissue ACE binding and cardiovascular outcomes compared to some other agents 8. When switching, consider not just dose equivalency but also the specific clinical indication and outcomes data for each agent.

Switching Protocol:

When converting between ACE inhibitors 1, 3:

  • Start at the calculated equivalent dose
  • Monitor blood pressure within 1-2 weeks
  • Check renal function and potassium within 1-2 weeks
  • Titrate based on response, not exceeding maximum doses from clinical trials
  • Watch for hypotension, hyperkalemia, and worsening renal function

Contraindications Apply Equally:

All ACE inhibitors share the same contraindications: history of angioedema, pregnancy, bilateral renal artery stenosis, and severe hyperkalemia (>5.0 mEq/L) 2, 3.

References

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.