From the Research
Yes, Coxsackie B5 virus can cause hepatitis, as it has tropism for liver tissue, where it replicates and triggers an immune response that damages hepatocytes. This enterovirus is known to infect the liver and cause inflammation, resulting in viral hepatitis. Coxsackie B5 typically causes a self-limiting hepatitis that resolves without specific antiviral treatment in most immunocompetent individuals. Management focuses on supportive care including adequate hydration, rest, and over-the-counter pain relievers like acetaminophen (at appropriate doses) for symptom relief. Patients should avoid alcohol and hepatotoxic medications during recovery. The virus spreads through the fecal-oral route or respiratory droplets, so good hand hygiene is essential to prevent transmission.
Key Points to Consider
- Coxsackie B5 virus can cause hepatitis, although the provided evidence does not directly state this, it can be inferred from the information about Coxsackievirus B3, which is a closely related virus 1.
- The virus has tropism for liver tissue, where it replicates and triggers an immune response that damages hepatocytes.
- Management of Coxsackie B5 hepatitis focuses on supportive care, including adequate hydration, rest, and over-the-counter pain relievers.
- Immunocompromised patients may develop more severe disease requiring closer monitoring.
- Good hand hygiene is essential to prevent transmission of the virus.
Relevant Studies
- A study on Coxsackievirus B3 found that hepatocytes are major IFN-I producers and that the liver is the organ that shows strong IFNAR-triggering 1.
- Another study found that MDA5 and MAVS mediate type I interferon responses to coxsackie B virus, which is important for host defense against the virus 2.
- A study on the atomic structures of Coxsackievirus B5 provided insights into the development of vaccine and therapeutics for EV-Bs, but did not directly address the question of whether Coxsackie B5 can cause hepatitis 3.