From the Research
Estradiol transdermal patches that are applied once weekly include Climara, which is specifically designed for weekly application, delivering a consistent dose of estradiol over seven days 1. The patch is typically applied to clean, dry skin on the lower abdomen or upper buttocks, and is replaced every 7 days. Some key points to consider when using these patches include:
- Dosages range from 0.025 mg to 0.1 mg per day, with the appropriate dose determined by your healthcare provider based on your symptoms and medical history 1.
- When starting hormone replacement therapy, it's common to begin with a lower dose and adjust as needed 1.
- These patches work by steadily releasing estrogen through the skin directly into the bloodstream, which helps maintain more consistent hormone levels compared to oral medications and avoids first-pass metabolism through the liver 2.
- Side effects may include skin irritation at the application site, breast tenderness, headaches, and nausea 1.
- It's essential to rotate application sites to prevent skin irritation and to follow your doctor's instructions regarding timing of application and dose adjustments 1.
- The buttocks seem to be an acceptable site for the application of this once-weekly 17-beta estradiol transdermal delivery system, and may provide an advantage in women who experience menopausal symptoms at the end of the week 3.
- Estradiol has been shown to have a protective effect against insulin resistance and obesity, in addition to its well-known benefits for menopausal symptoms and osteoporosis 4.