What are the potential causes of cardiac arrest in a healthy, young, active male with a history of Lyme (Lyme disease)?

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Last updated: May 23, 2025View editorial policy

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Differential Diagnosis for Cardiac Arrest in a Healthy, Young Active Male with a History of Lyme

  • Single most likely diagnosis:
    • Lyme carditis: This is a well-known complication of Lyme disease, which can cause cardiac conduction abnormalities, including heart block, and potentially lead to cardiac arrest. The patient's history of Lyme disease makes this a highly plausible diagnosis.
  • Other Likely diagnoses:
    • Hypertrophic cardiomyopathy: This is a common cause of sudden cardiac death in young athletes. Although the patient is described as healthy, hypertrophic cardiomyopathy can be asymptomatic until a catastrophic event occurs.
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC): Another condition that can lead to sudden cardiac death, especially in young, active individuals. It may not have been previously diagnosed.
    • Coronary artery anomalies: These are congenital abnormalities of the coronary arteries that can increase the risk of cardiac arrest during intense physical activity.
  • Do Not Miss diagnoses:
    • Pulmonary embolism: Although less common in young, healthy individuals, a pulmonary embolism can cause cardiac arrest and must be considered, especially if there are any risk factors for thromboembolism.
    • Aortic dissection: This is a life-threatening condition that requires immediate diagnosis and treatment. It can present with sudden onset of chest pain and can lead to cardiac arrest.
    • Commotio cordis: A blunt trauma to the chest that can cause cardiac arrest, often in the context of sports activities.
  • Rare diagnoses:
    • Brugada syndrome: A genetic disorder that affects the heart's electrical system and can lead to life-threatening arrhythmias.
    • Catecholaminergic polymorphic ventricular tachycardia (CPVT): A rare genetic disorder that can cause sudden cardiac death, especially during physical activity or emotional stress.
    • Myocarditis from other causes: While Lyme carditis is a consideration, myocarditis from viral or other bacterial infections could also lead to cardiac arrest in a young, otherwise healthy individual.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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