From the Research
Compounded topical anti-inflammatory medications and tacrolimus are a viable treatment option for various dermatological conditions in the USA, with high-dose tacrolimus (0.1%) being among the most effective treatments for atopic dermatitis, as evidenced by a 2023 systematic review and network meta-analysis 1. The use of compounded topicals for anti-inflammatory and tacrolimus in the USA is supported by recent studies, which highlight their efficacy and safety in treating conditions like atopic dermatitis, psoriasis, and vitiligo.
- Key benefits of compounded topicals include customized strengths, combinations of medications, and allergen-free formulations, which can enhance efficacy and reduce side effects.
- Tacrolimus, in particular, has been shown to be effective in inhibiting calcineurin to reduce inflammation without the side effects of steroids, with high-dose tacrolimus (0.1%) being among the most effective treatments for atopic dermatitis 1.
- A 2018 review of tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis found that it is effective and well-tolerated, with negligible systemic drug absorption and no strong evidence of an increased rate of malignancy in treated patients 2.
- However, it is essential to note that insurance coverage for compounded medications varies significantly, and patients should verify coverage before proceeding.
- Compounding pharmacies must comply with USP standards and state regulations, ensuring quality and safety of the customized formulations.
- The efficacy of these compounded topicals stems from their anti-inflammatory and immunomodulatory properties, making them a valuable treatment option for patients who require specific concentrations, combinations of medications, or allergen-free formulations not available commercially.