What is the diagnosis for a 31-year-old individual with a history of health anxiety, experiencing persistent and intense emotional distress, characterized by feelings of torment, weepiness, and dark emotions, despite normal laboratory results, including vitamin D, iron, B12, magnesium, and calcium levels, and a methylation report showing impaired folate and BH4 cycles, after a course of Sertraline (selective serotonin reuptake inhibitor) and supplementation with 5-Hydroxytryptophan (5-HTP)?

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Last updated: May 23, 2025View editorial policy

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Differential Diagnosis

Single most likely diagnosis

  • Anxiety Disorder, specifically Health Anxiety: The patient's history of excessive worry about their health, frequent reassurance seeking, and preoccupation with the possibility of having a serious illness (e.g., long COVID, heart conditions) are all consistent with health anxiety. The patient's symptoms of agitation, distress, and torment may be manifestations of this anxiety.

Other Likely diagnoses

  • Adjustment Disorder: The patient's symptoms of emotional distress, anxiety, and depression may be related to significant life changes, such as moving to a new apartment, starting a new relationship, and experiencing a traumatic event (e.g., the hospital visit).
  • Panic Disorder: The patient's experience of panic attacks, agoraphobia, and avoidance behaviors are consistent with panic disorder.
  • Depressive Disorder, NOS (Not Otherwise Specified): Although the psychiatrist ruled out depression, the patient's symptoms of low mood, anhedonia, and suicidal ideation may suggest a depressive disorder.

Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)

  • Cardiovascular Disease: Although the patient's tests have been negative, it is essential to continue monitoring their cardiovascular health, given their history of chest pain and heart palpitations.
  • Neurological Disorders (e.g., Multiple Sclerosis, Parkinson's Disease): Although the patient's symptoms do not strongly suggest a neurological disorder, it is crucial to consider these possibilities, given the potential for severe consequences if left undiagnosed.

Rare diagnoses

  • Mitochondrial Myopathies: The patient's symptoms of fatigue, anxiety, and depression, combined with their history of COVID-19, may suggest a mitochondrial myopathy, although this is a rare and unlikely diagnosis.
  • Postural Orthostatic Tachycardia Syndrome (POTS): The patient's symptoms of anxiety, palpitations, and orthostatic intolerance may be consistent with POTS, although this diagnosis would require further evaluation.

Relevance of the therapy session

The therapy session may have triggered the patient's emotional distress, as they reported feeling a "dark cloud" wash over them after the session. This could be related to the patient's health anxiety and fear of losing control.

Is this Agitated Depression?

While the patient's symptoms of agitation, anxiety, and depression are consistent with agitated depression, the psychiatrist's evaluation suggested that the patient's symptoms were more consistent with a state of emotional angst rather than depression. However, it is possible that the patient's symptoms could be related to a depressive disorder, and further evaluation would be necessary to determine the underlying cause of their symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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