From the Research
Several medications in this list can potentially interfere with testosterone levels, including psychiatric medications, anticonvulsants, and statins, which may cause a decrease in testosterone production or affect sexual function. The medications that can potentially interfere with testosterone levels include:
- Propranolol, a beta-blocker, which may cause erectile dysfunction and decrease libido
- Lisinopril, an ACE inhibitor, which generally has minimal effects on testosterone but can occasionally impact sexual function
- Psychiatric medications including bupropion, quetiapine, sertraline, and buspirone, which can affect sexual function and potentially testosterone levels, with sertraline (an SSSI) being particularly known for causing sexual side effects 1
- Rosuvastatin and fenofibrate, which treat cholesterol, and may slightly lower testosterone levels in some individuals, as supported by a study that found statins can lower testosterone by -0.44 nmol/l (95% CI -0.75 to -0.13) 2
- Divalproex sodium and oxcarbazepine, both anticonvulsants, which can potentially decrease testosterone production
- The antipsychotic medications Abilify Maintena (aripiprazole) and quetiapine, which may cause elevated prolactin levels, which can indirectly lower testosterone, as noted in a study that found quetiapine to be a common medication used in combination therapy for bipolar depression 3 If experiencing symptoms of low testosterone while taking these medications, it would be advisable to discuss this with a healthcare provider who can order appropriate testing and consider medication adjustments if necessary.