From the Research
For patients on Epuris (isotretinoin) for 2 months, recommended blood work should include liver function tests (ALT, AST), lipid profile (cholesterol, triglycerides), and pregnancy testing for females of childbearing potential. These tests are essential to monitor the potential side effects of isotretinoin, which can cause elevations in liver enzymes and blood lipids, as well as its teratogenic effects 1. The monitoring schedule should include tests at baseline, after 1 month of therapy, and then at the 2-month mark, with the option to adjust the frequency based on the initial results and the patient's risk factors 2. Some clinicians may also consider monitoring complete blood count and fasting glucose, although these are less commonly affected by isotretinoin therapy 3. It is crucial to perform these blood tests while fasting (at least 8 hours) to ensure accurate lipid measurements and to review the results before providing the next month's prescription to ensure patient safety. Liver enzyme elevations above 3 times the upper limit of normal or triglycerides above 800 mg/dL may require dose adjustment or discontinuation of the medication 1. Key points to consider when monitoring patients on Epuris include:
- Liver function tests (ALT, AST) to detect potential liver damage
- Lipid profile (cholesterol, triglycerides) to monitor for hyperlipidemia
- Pregnancy testing for females of childbearing potential due to the teratogenic effects of isotretinoin
- Optional monitoring of complete blood count and fasting glucose
- Adjusting the monitoring schedule based on initial results and patient risk factors
- Ensuring patient safety by reviewing results before providing the next month's prescription.