What is the failure rate of the Watchman (Left Atrial Appendage Closure Device) for stroke prevention?

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Last updated: May 23, 2025View editorial policy

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From the Research

The Watchman device has a relatively low failure rate for stroke prevention in patients with atrial fibrillation, with a procedural success rate of approximately 95% and a failure rate of about 5%, as demonstrated in the most recent study 1. The device reduces stroke risk by approximately 80% compared to no treatment, which is comparable to warfarin therapy. However, there are specific risks associated with the procedure, including a 2-3% risk of serious complications such as pericardial effusion, device embolization, or procedure-related stroke. Some key points to consider when evaluating the Watchman device for stroke prevention in patients with atrial fibrillation include:

  • The device works by physically closing off the left atrial appendage where most stroke-causing blood clots form in atrial fibrillation patients.
  • Patients require post-procedure anticoagulation therapy, typically with warfarin for 45 days followed by dual antiplatelet therapy for 6 months, then lifelong aspirin.
  • Long-term device-related thrombus formation occurs in about 3-4% of patients, which may increase stroke risk if not managed properly.
  • Regular follow-up with echocardiography is essential to ensure proper device positioning and function.
  • Patient selection is crucial, as those with certain anatomical features or contraindications to short-term anticoagulation may not be suitable candidates, as noted in studies 2, 3. The most recent and highest quality study 1 supports the use of the Watchman device as a viable option for stroke prevention in patients with atrial fibrillation, particularly those with contraindications to anticoagulation. Some of the benefits of the Watchman device include:
  • Reduced risk of stroke and systemic embolism
  • Lower risk of major bleeding compared to long-term anticoagulation
  • Potential for improved quality of life and reduced morbidity and mortality. Overall, the Watchman device is a valuable treatment option for patients with atrial fibrillation who are at high risk of stroke and systemic embolism, and who may not be suitable candidates for long-term anticoagulation, as supported by the evidence 1, 4.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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