There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for hydralazine (PO), lisinopril (PO) do not address this question.
From the Research
Comparative Efficacy of Hydralazine and Lisinopril
- The comparative efficacy of hydralazine versus lisinopril in patients with elevated creatine kinase (CK) levels is not directly addressed in the provided studies.
- However, study 1 compared the effects of lisinopril and hydralazine on left ventricular hypertrophy and ambulatory blood pressure monitoring in essential hypertension, and found that lisinopril was more effective in reducing night-time systolic and diastolic blood pressure.
- Study 1 also found that lisinopril significantly reduced left ventricular mass, whereas hydralazine did not.
- Study 2 reported a case of rhabdomyolysis in a patient receiving ranolazine and simvastatin, and noted that the patient was also taking hydralazine, but did not suggest that hydralazine was the cause of the rhabdomyolysis.
- Study 3 investigated the effects of hydralazine on ischemia-induced neovasculogenesis in chronic renal insufficiency, and found that hydralazine improved neovasculogenesis and reduced oxidative stress.
- Study 4 compared the efficacy and tolerability of lisinopril and sustained-release verapamil in older patients with hypertension, and found that both drugs were equally effective in reducing blood pressure.
- Study 5 compared the effectiveness of enalapril, lisinopril, and ramipril in the treatment of patients with chronic heart failure, and found that the three drugs were equally effective when given at equivalent doses 5.
Effects on Creatine Kinase Levels
- None of the provided studies directly compared the effects of hydralazine and lisinopril on creatine kinase (CK) levels.
- Study 2 reported a case of rhabdomyolysis with elevated CK levels in a patient taking hydralazine, among other medications, but did not provide a comparison with lisinopril 2.
- The effects of hydralazine and lisinopril on CK levels in patients with elevated CK levels are not well established based on the provided studies.