From the Research
Patients taking levetiracetam and lamotrigine should exercise caution when considering ashwagandha supplements, as potential interactions may occur, and consult their neurologist or healthcare provider before starting ashwagandha supplements. Ashwagandha has mild GABA-enhancing properties which could potentially increase the sedative effects of these medications, and it might affect liver enzymes involved in metabolizing these drugs, potentially altering their blood levels 1. The safety of this combination has not been extensively studied, and maintaining stable blood levels of anti-seizure medications is crucial for seizure control, so any supplement that might interfere with this should be approached with caution.
Some studies suggest that ashwagandha may have beneficial effects on anxiety and stress levels, with a systematic review and meta-analysis finding that ashwagandha supplementation significantly reduced anxiety and stress levels compared to a placebo 2. However, the certainty of the evidence was low, and further high-quality studies are needed to firmly establish the clinical efficacy of ashwagandha.
If approved by a healthcare provider, patients should start with a low dose of ashwagandha and monitor for increased side effects such as dizziness, drowsiness, or changes in seizure control. Any unusual symptoms should prompt immediate medical attention. It is essential to prioritize the patient's safety and well-being, and healthcare providers should use their clinical judgment to determine the risks and benefits of ashwagandha supplements in combination with levetiracetam and lamotrigine 3.
Key considerations for patients taking levetiracetam and lamotrigine who want to start ashwagandha supplements include:
- Consulting their neurologist or healthcare provider before starting ashwagandha supplements
- Starting with a low dose of ashwagandha and monitoring for increased side effects
- Being aware of potential interactions between ashwagandha and their anti-seizure medications
- Prioritizing their safety and well-being, and seeking immediate medical attention if unusual symptoms occur.