From the Research
Pregnenolone supplementation is considered for patients with adrenal insufficiency, cognitive decline, depression, fatigue, or hormonal imbalances, particularly in aging individuals with declining natural pregnenolone levels, with typical dosages ranging from 10-100 mg daily 1. The use of pregnenolone supplementation is not FDA-approved for any specific condition, but some healthcare providers may recommend it for certain patients.
- Adrenal insufficiency is a potential indication for pregnenolone supplementation, as it can help alleviate symptoms of fatigue and hormonal imbalances 2.
- Cognitive decline and depression are also potential indications, as pregnenolone has been shown to have neuroprotective effects and may help improve mood 1.
- Hormonal imbalances, particularly in aging individuals with declining natural pregnenolone levels, may also be an indication for supplementation 3. However, evidence supporting the use of pregnenolone remains largely anecdotal or from small studies, and patients should be aware of the potential risks and interactions with other medications 4, 5. Before starting supplementation, individuals should undergo appropriate hormone testing and consult with a healthcare provider knowledgeable about bioidentical hormones, as self-supplementation without monitoring could lead to hormonal imbalances or mask underlying conditions. Key points to consider when recommending pregnenolone supplementation include:
- Typical dosages range from 10-100 mg daily, though some practitioners may recommend up to 200 mg for specific conditions.
- Pregnenolone serves as a precursor to many hormones, including cortisol, DHEA, progesterone, and testosterone, which explains its potential wide-ranging effects.
- As a supplement, pregnenolone lacks standardized quality control and may interact with hormone-related medications.