What is the recommended meropenem (Meropenem) plus sulbactam (Sulbactam) dosing regimen for resistant Acinetobacter strains?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 24, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Dirençli Acinetobacter suşlarında meropenem-sulbaktam tedavisi için önerilen doz genellikle meropenem 1-2g ile sulbaktam 1-2g'nin kombinasyonudur ve bu kombinasyon intravenöz olarak her 8 saatte bir uygulanır. 1 Aşağıdaki nedenlerle bu dozaj önerilir:

  • Dirençli Acinetobacter suşlarında yüksek doz meropenem ve sulbaktam kullanılması gerekebilir, özellikle severe enfeksiyonlar veya yüksek düzeyde dirençli suşlar için 2.
  • Böbrek yetmezliği olan hastalarda dozaj ayarlaması yapılmalıdır 3.
  • Meropenem'in uzatılmış veya sürekli infüzyonu (standart 30 dakikadan ziyade 3-4 saat) etkinliği artırabilir 4.
  • Bu kombinasyon, meropenem'in hücre duvarı sentezini inhibe etmesi ve sulbaktamın beta-laktamaz enzimleri inhibe etmesi yoluyla çalışır 5. Tedavi süresi genellikle enfeksiyon sitesi ve şiddetine bağlı olarak 7-14 gün arasında değişir, ancak pnömoni veya bakteremi gibi karmaşık enfeksiyonlar için daha uzun süreli tedavilere ihtiyaç duyulabilir 1.

References

1
Research

Treatment of infections caused by carbapenem-resistant Acinetobacter baumannii.

Frontiers in cellular and infection microbiology, 2024

4
Research

Treatment of Acinetobacter infections.

Expert opinion on pharmacotherapy, 2010

5
Research

Antibacterial activity of carbapenem-based combinations againts multidrug-resistant Acinetobacter baumannii.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2010

Related Questions

What are the treatment combinations for resistant Acinetobacter (A. baumannii) infections?
What is the comparative efficacy of fosfomycin and sulbactam-based treatment regimens for multidrug-resistant Acinetobacter infections?
What is the treatment outcome for Acinetobacter species infections?
What is the recommended treatment for Acinetobacter pneumonia?
What are the treatment options for carbapenem-resistant Acinetobacter baumannii infections?
What are the possible diagnoses and is cerebral imaging indicated for a 36-year-old female with transient bilateral peripheral field loss and visual blurring after a traumatic fall, with a history of migraines (migraine headaches) and no current headache or loss of consciousness?
What are the recommended doses of Fosfomycin and Meropenem in combination for the treatment of pneumonia caused by resistant Klebsiella (Klebsiella pneumoniae)?
What causes elevated lymphocyte (white blood cell) count, also known as lymphocytosis?
What is the recommended dose of Propranolol (propranolol hydrochloride) for the treatment of vestibular migraines?
What are Cytomegalovirus (CMV) symptoms?
What are the antibiotic combination therapies for resistant Pseudomonas aeruginosa pneumonia?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.

Ask Question