Is there an association between adult-onset asthma and Human Papillomavirus (HPV) infection?

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Last updated: February 21, 2025View editorial policy

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From the Guidelines

There is currently no established direct link between adult-onset asthma and HPV infection, and the most recent evidence does not support a definitive connection between the two conditions. Adult-onset asthma is typically triggered by factors such as allergies, respiratory infections, occupational exposures, or hormonal changes, as noted in a study published in the European Respiratory Review in 2021 1. HPV (Human Papillomavirus) primarily affects the genital and oral regions and is not known to directly impact the respiratory system.

If you are experiencing asthma-like symptoms as an adult, you should:

  • Consult a healthcare provider for proper diagnosis and treatment.
  • Undergo lung function tests, such as spirometry.
  • Consider allergy testing to identify potential triggers.
  • Follow prescribed treatment, which may include:
    • Inhaled corticosteroids (e.g., fluticasone, budesonide)
    • Short-acting beta-agonists for quick relief (e.g., albuterol)
    • Long-acting beta-agonists for ongoing control (e.g., salmeterol) While managing asthma, it's also important to:
  • Avoid known triggers
  • Maintain a healthy lifestyle
  • Get vaccinated against respiratory infections

Regarding HPV, it's recommended to:

  • Get vaccinated if you're eligible (typically before age 26)
  • Have regular cervical cancer screenings for women
  • Practice safe sex to reduce transmission risk Understanding the distinction between these conditions is crucial for proper management, and a study published in Otolaryngology--head and neck surgery in 2015 highlights the importance of diagnosing and treating comorbidities associated with allergic rhinitis, which may be relevant to asthma management 1. If you have concerns about either asthma or HPV, consult with your healthcare provider for personalized advice and treatment options.

From the Research

Association between Adult-Onset Asthma and Human Papillomavirus (HPV) Infection

  • There is limited direct evidence on the association between adult-onset asthma and Human Papillomavirus (HPV) infection 2, 3, 4, 5.
  • However, a study on adult-onset recurrent respiratory papillomatosis (AO-RRP) suggests that HPV infection may play a role in the development of respiratory diseases in adults 6.
  • AO-RRP is a rare manifestation of HPV infection, and nearly 100% of patients with AO-RRP had concurrent oral cavity HPV infection 6.
  • The mechanism(s) underlying the progression from HPV infection to AO-RRP remains unknown, and it is unclear if HPV infection is also associated with adult-onset asthma 6.
  • Other studies suggest that respiratory infections, including those caused by Chlamydia pneumoniae, may be associated with adult-onset asthma 5.
  • Adult-onset asthma is a complex disease with multiple risk factors, including obesity, smoking, depression, and environmental factors, and the role of HPV infection in its development is not well understood 3, 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Adult-onset asthma.

Australian family physician, 2015

Research

Asthma and chlamydial infection: a case series.

The Journal of family practice, 1994

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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