What is the likely cause of a pruritic (itchy) rash that starts at both external ears then spreads to the rest of the body, with no airway involvement?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 24, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Pruritic Rash

The following differential diagnosis is organized into categories to help guide the thought process:

  • Single most likely diagnosis
    • Contact dermatitis: This is a common condition that can cause a pruritic rash, especially if the patient has come into contact with an allergen or irritant, such as nickel in earrings. The rash often starts at the site of contact, in this case, the external ears, and can spread to other areas.
  • Other Likely diagnoses
    • Atopic dermatitis (eczema): This is a chronic skin condition characterized by itchy, inflamed skin. It can start at any age and may be triggered by allergies or environmental factors.
    • Seborrheic dermatitis: This condition causes a red, itchy rash, often on the scalp, but can also occur on the ears and spread to other areas.
    • Allergic reaction: An allergic reaction to a medication, food, or other substance can cause a pruritic rash that starts in one area and spreads.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Stevens-Johnson syndrome: Although rare, this is a life-threatening condition that can cause a rash, often starting on the face and ears, and can progress to involve the mucous membranes and other areas.
    • Toxic epidermal necrolysis: Similar to Stevens-Johnson syndrome, this is a severe skin condition that can be fatal if not promptly treated.
  • Rare diagnoses
    • Pityriasis rubra pilaris: A rare skin disorder that causes a rash, often starting on the face and ears, and can spread to other areas.
    • Keratosis follicularis (Darier's disease): A rare genetic disorder that affects the skin and can cause a rash, often starting on the face and ears.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.