Differential Diagnosis for Upper Lip Swelling
Single Most Likely Diagnosis
- Allergic Reaction: This is often the most common cause of sudden upper lip swelling, typically resulting from an allergic response to food, insect bites, or other environmental factors. The reaction can be localized or part of a more systemic anaphylactic response.
Other Likely Diagnoses
- Trauma: Direct injury to the upper lip can cause swelling due to inflammation and hematoma formation.
- Infection: Bacterial or viral infections, such as impetigo or herpes simplex, can lead to swelling of the upper lip.
- Dental Issues: Problems like abscesses or infections of the teeth or gums can cause swelling in the adjacent areas, including the upper lip.
Do Not Miss Diagnoses
- Angioedema: A potentially life-threatening condition that can cause rapid swelling of the lips, face, and airways, often associated with allergic reactions or hereditary conditions.
- Cellulitis: A bacterial skin infection that can spread rapidly and cause significant morbidity if not treated promptly.
- Necrotizing Fasciitis: A rare but severe infection that destroys tissue under the skin, requiring immediate medical attention.
Rare Diagnoses
- Melkersson-Rosenthal Syndrome: A rare neurological disorder characterized by recurrent, often unilateral, facial paralysis or weakness, swelling of the face and lips, and the development of folds and furrows in the tongue.
- Sarcoidosis: An autoimmune disease that can cause swelling and lesions in various parts of the body, including the face and lips, though this is less common.
- Lip Cancer: Though rare, cancers of the lip can present with swelling, especially if they become infected or ulcerated.