From the Research
Vitamin B complex supplements are unlikely to trigger migraines in most individuals, and may even have a positive effect on reducing migraine frequency and severity, as evidenced by the most recent and highest quality study 1. When considering the relationship between vitamin B complex and migraines, it's essential to examine the available evidence.
- The study published in 2022 2 found that supplementation with thiamine (B1), pyridoxine (B6), cobalamin (B12), folic acid (B9), and a combination of these vitamins decreased the frequency of headache attacks and improved migraine disability scores in women with episodic migraine.
- Another study published in 2025 1 recommended riboflavin or vitamin B2 for migraine prevention in adults, citing minimal adverse events.
- A systematic review and meta-analysis published in 2022 3 found that Vitamin B2 supplementation significantly decreased migraine days, duration, frequency, and pain score.
- While some studies suggest that high doses of certain B vitamins, such as vitamin B6, may trigger migraines in susceptible individuals, the current evidence does not support a causal relationship between vitamin B complex supplements and migraines.
- In fact, the most recent and highest quality study 1 suggests that vitamin B complex supplements may be beneficial in reducing migraine frequency and severity, making them a potential adjunct therapy for migraine management. It's crucial to consult with a healthcare provider before starting or stopping any supplement, especially if it was prescribed for a specific condition.
- If you experience migraines and are taking vitamin B complex supplements, consider speaking with your healthcare provider about the potential benefits and risks of continuing or adjusting your supplement regimen.
- Additionally, focusing on getting B vitamins through natural food sources like whole grains, leafy greens, eggs, and lean meats may be a viable alternative for those who experience migraines or are sensitive to supplements.