What is the cause of chest pain or heaviness, lightheadedness, sore throat, and tingling sensation in the wrist?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 25, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Chest Pain or Heaviness, Lightheadedness, Sore Throat, and Tingling in the Wrist

  • Single Most Likely Diagnosis
    • Acute Coronary Syndrome (ACS): This condition, which includes myocardial infarction (heart attack) and unstable angina, is a leading cause of chest pain and can also cause lightheadedness due to decreased cardiac output. The sore throat could be referred pain, and tingling in the wrist might be related to anxiety or stress response, although it's less directly related. ACS is a common and critical condition that matches several of the symptoms provided.
  • Other Likely Diagnoses
    • Anxiety or Panic Attack: These conditions can cause chest pain or heaviness, lightheadedness, and tingling sensations in various parts of the body, including the wrists. A sore throat could be due to hyperventilation. Anxiety and panic attacks are relatively common and can mimic more serious conditions.
    • Gastroesophageal Reflux Disease (GERD): GERD can cause chest pain and sore throat. While less likely to cause lightheadedness or wrist tingling directly, the discomfort could lead to anxiety, which might exacerbate these symptoms.
  • Do Not Miss Diagnoses
    • Pulmonary Embolism (PE): Although less common, PE is a potentially life-threatening condition that can cause sudden onset of chest pain and lightheadedness. A sore throat is less typical but could be present if the PE is associated with other conditions like a respiratory infection. Tingling in the wrist is not a typical symptom but could occur in the context of severe anxiety or hypoxia.
    • Aortic Dissection: This is a serious condition where there is a tear in the aorta's wall, which can cause severe chest pain and potentially lead to lightheadedness if there's significant blood loss or aortic valve involvement. While a sore throat and wrist tingling are not typical symptoms, the severity and potential for rapid deterioration make this a "do not miss" diagnosis.
  • Rare Diagnoses
    • Mitral Valve Prolapse: This condition can cause chest pain, palpitations, and potentially lightheadedness if there's significant mitral regurgitation. However, sore throat and wrist tingling are not typical symptoms, making this a less likely diagnosis.
    • Thoracic Outlet Syndrome: This condition involves compression of the nerves and/or blood vessels that pass into the thoracic outlet (the space between your collarbone and first rib). It can cause chest pain, tingling in the arms, and potentially lightheadedness if there's significant vascular compression. A sore throat could be related to the compression of nerves. While it's a possible diagnosis, it's less common and the combination of symptoms might not perfectly align.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.