What is the clinical significance of a liver lesion and ovarian vein thrombosis with suspected pelvic congestion syndrome?

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Last updated: February 21, 2025View editorial policy

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Differential Diagnosis

  • Single most likely diagnosis
    • Focal liver lesion (possibly hepatocellular carcinoma or metastasis): The 17 mm process in the liver with homogeneous contrast uptake in the arterial phase and some washout in the venous phase, along with central contrast retention, raises suspicion for a malignant liver tumor.
  • Other Likely diagnoses
    • Pelvic congestion syndrome: The presence of varicose veins in the pelvis, related to the uterus, and an 11 mm long thrombus in the left ovarian vein with collateral circulation, supports this diagnosis.
    • Hemangioma: Although less likely given the description, a hemangioma could present as a focal liver lesion with characteristic contrast enhancement patterns.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Liver metastasis: Given the presence of a focal liver lesion, metastasis from an unknown primary tumor or a known cancer should be considered to ensure timely and appropriate management.
    • Hepatocellular carcinoma: As mentioned, the liver lesion's characteristics could be indicative of hepatocellular carcinoma, which is a serious condition requiring prompt diagnosis and treatment.
    • Thrombosis of the ovarian vein with potential for pulmonary embolism: The thrombus in the ovarian vein, although with collateral circulation, poses a risk for pulmonary embolism, which is a life-threatening condition.
  • Rare diagnoses
    • Focal nodular hyperplasia (FNH): A rare benign liver tumor that could present with similar imaging characteristics, although typically it has a central scar and a more homogeneous appearance.
    • Intrahepatic cholangiocarcinoma: A rare malignant tumor of the bile ducts within the liver, which could present as a focal liver lesion but is less common than hepatocellular carcinoma or metastasis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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