From the Research
For a two and a half-year-old child weighing 15 kg, the recommended dose of sublingual Zofran (ondansetron) is 2 mg, based on the pediatric dosing guideline of 0.1-0.15 mg/kg per dose, with a maximum of 4 mg per dose for children under 4 years old 1.
Key Considerations
- The medication can be given every 8 hours as needed for nausea and vomiting, with a maximum of three doses per day.
- The sublingual tablet should be placed under the child's tongue and allowed to dissolve completely without chewing or swallowing it whole.
- It's essential to monitor the child for side effects, which may include headache, drowsiness, or constipation.
- If vomiting persists despite medication, or if the child shows signs of dehydration (dry mouth, decreased urination, lethargy), seek medical attention promptly.
Mechanism of Action
Ondansetron works by blocking serotonin receptors in the brain and gut that trigger nausea and vomiting, making it effective for managing these symptoms in children.
Evidence Summary
While multiple studies support the use of ondansetron for nausea and vomiting, the most relevant and recent study for this specific question is not directly provided in the given evidence. However, based on the general guidelines and the provided studies, the recommended dose for a child of this age and weight is consistent with standard pediatric dosing guidelines 1.
Administration and Monitoring
- Administer the medication as directed, and ensure the child does not chew or swallow the sublingual tablet whole.
- Monitor for side effects and adjust the treatment plan as necessary.
- Seek medical attention if symptoms worsen or if the child shows signs of dehydration.