What are the haematological causes of a 16-year-old female experiencing menorrhagia (heavy menstrual bleeding) with severe anaemia (haemoglobin (Hb) level of 6.6 g/dL)?

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Differential Diagnosis for Heavy Menstrual Cycle and Low Hemoglobin

Single Most Likely Diagnosis

  • Iron Deficiency Anemia: This is the most likely diagnosis given the patient's heavy menstrual cycle and low hemoglobin level (6.6 g/dL). Heavy menstrual bleeding is a common cause of iron deficiency anemia in adolescent females.

Other Likely Diagnoses

  • Dysfunctional Uterine Bleeding: This condition is characterized by abnormal uterine bleeding that is not associated with any underlying medical condition. It is a common cause of heavy menstrual bleeding in adolescents.
  • Thyroid Disorders: Both hypothyroidism and hyperthyroidism can cause heavy menstrual bleeding. Thyroid function tests should be performed to rule out these conditions.
  • Von Willebrand Disease: This is a bleeding disorder that can cause heavy menstrual bleeding. It is more common in females and can be diagnosed with laboratory tests.

Do Not Miss Diagnoses

  • Bleeding Disorders (e.g., Hemophilia, Factor XI Deficiency): Although less common, these conditions can cause severe bleeding and should not be missed.
  • Uterine Anomalies or Tumors: Conditions such as uterine fibroids or anomalies can cause heavy menstrual bleeding and should be ruled out with imaging studies.
  • Coagulopathy (e.g., Disseminated Intravascular Coagulation, Thrombocytopenia): These conditions can cause severe bleeding and should be considered in the differential diagnosis.

Rare Diagnoses

  • Hereditary Hemorrhagic Telangiectasia: This is a rare genetic disorder that can cause bleeding from multiple sites, including the uterus.
  • Systemic Lupus Erythematosus: This autoimmune disorder can cause a variety of symptoms, including heavy menstrual bleeding.
  • Leiomyosarcoma: This is a rare type of uterine cancer that can cause heavy menstrual bleeding.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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