Is there a combined COVID-19 and influenza vaccine available?

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Last updated: July 18, 2026 • View editorial policy

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Combined COVID-19 and Influenza Vaccine Availability

Yes, combination COVID-19 and influenza vaccines are currently in development and clinical trials, but none are yet FDA-approved or authorized for use in the United States as of the 2024-2025 season. You will need to administer separate COVID-19 and influenza vaccines.

Current Vaccination Strategy

For the 2024-2025 season, you must give:

  • Separate COVID-19 vaccine (2024-2025 formulation based on KP.2 or JN.1 strains) 1
  • Separate influenza vaccine (trivalent formulation for 2024-25 season) 2

These can be administered simultaneously at different anatomic sites, which is safe and recommended by ACIP 2.

Combination Vaccines in Development

Multiple combination COVID-19/influenza vaccines are in late-stage development:

  • Moderna's mRNA-1083: A dual-target mRNA vaccine showing strong immunogenicity and favorable safety profiles in clinical trials 3
  • Pfizer's mRNA-1020/1030: Another mRNA-based combination vaccine demonstrating good performance, though slightly less effective against influenza B compared to Moderna's candidate 3
  • Matrix-M-adjuvanted combination vaccines: Clinical trials involving 1,422 participants have shown these combination influenza-COVID-19 (CIC) vaccines are well-tolerated with favorable safety profiles 4

Animal studies have demonstrated that combination vaccines provide equivalent protection to monovalent vaccines without evidence of vaccine interference 5, 6.

Practical Guidance for Now

Administer both vaccines at the same visit but in different anatomic sites 2. Key considerations:

  • If using high-dose or adjuvanted influenza vaccines (HD-IIV3 or aIIV3), give them in different limbs from the COVID-19 vaccine to minimize local reactions 2
  • Do not delay influenza vaccination waiting for a combination product
  • Both vaccines are recommended for all persons aged ≥6 months 2, 1

Timeline Expectations

While combination vaccines show promise in Phase 3 trials 7, regulatory approval and market availability will likely take additional time beyond the current 2024-2025 season. The technology has been validated, but formal FDA approval processes are still ongoing.

References

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.