Is there a relationship between uterine fibroids (leiomyomas) and alopecia (hair loss)?

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From the Guidelines

Fibroids and hair loss are not directly connected, but they may share common underlying factors, such as hormonal imbalances, particularly involving estrogen and progesterone, which can contribute to both uterine fibroids and hair thinning in women. If you're experiencing both conditions, consider consulting with both a gynecologist for fibroid management and a dermatologist for hair loss treatment. For fibroids, treatment options depend on severity and symptoms, ranging from watchful waiting to medications like GnRH agonists (leuprolide acetate) or surgical interventions, as outlined in the American College of Radiology's guidelines 1. For hair loss, minoxidil 2% solution applied twice daily to the scalp is the primary FDA-approved treatment for women.

Iron deficiency can worsen both conditions, especially if fibroids cause heavy menstrual bleeding, so taking an iron supplement (ferrous sulfate 325mg daily) may help if tests show deficiency, as iron plays a crucial role in hair growth and its deficiency can lead to hair loss 1. Stress management techniques are also beneficial as chronic stress can exacerbate both conditions. While treating fibroids, some medications like GnRH agonists might temporarily worsen hair loss as a side effect, so discuss this concern with your doctor who may adjust treatment or add supportive therapies for your hair during fibroid treatment.

Some key points to consider:

  • Hormonal imbalances, particularly involving estrogen and progesterone, can contribute to both uterine fibroids and hair thinning in women 1
  • Iron deficiency can worsen both conditions, especially if fibroids cause heavy menstrual bleeding 1
  • Stress management techniques are beneficial as chronic stress can exacerbate both conditions
  • Treatment options for fibroids depend on severity and symptoms, ranging from watchful waiting to medications like GnRH agonists (leuprolide acetate) or surgical interventions 1
  • Minoxidil 2% solution applied twice daily to the scalp is the primary FDA-approved treatment for women with hair loss.

It's essential to consult with healthcare professionals to determine the best course of treatment for both conditions, considering the potential interactions between fibroid and hair loss treatments 1.

From the Research

Fibroid and Hair Loss

  • There is no direct evidence in the provided studies that links fibroids to hair loss 2, 3, 4, 5, 6.
  • The studies focus on the diagnosis, management, and treatment of uterine fibroids, including hormonal therapies such as gonadotropin-releasing hormone (GnRH) agonists and antagonists 2, 3, 4, 5.
  • Some studies discuss the use of add-back therapy with GnRH analogues to limit side effects, but hair loss is not mentioned as a symptom or side effect 6.
  • The provided studies do not investigate the relationship between fibroids and hair loss, and therefore, there is no evidence to support or refute a link between the two conditions 2, 3, 4, 5, 6.

Treatment Options for Uterine Fibroids

  • Medical treatments, including hormonal therapies, are considered the first-line treatment for symptomatic uterine fibroids 2, 3, 4.
  • GnRH agonists and antagonists are effective in reducing fibroid volume and symptomatic improvement in menstrual bleeding 4, 5.
  • Add-back therapy with certain medications may help limit the side effects of GnRH analogues, but the evidence is limited and of low to moderate quality 6.

Symptoms and Effects of Uterine Fibroids

  • Uterine fibroids can cause a range of symptoms, including heavy or prolonged menstrual bleeding, pelvic pain, infertility, and recurrent pregnancy loss 3, 4.
  • The symptoms and effects of uterine fibroids can vary widely, and some women may experience no symptoms at all 3, 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Diagnosis and management of uterine fibroids: current trends and future strategies.

Journal of basic and clinical physiology and pharmacology, 2023

Research

Current medical treatment of uterine fibroids.

Obstetrics & gynecology science, 2018

Research

Add-back therapy with GnRH analogues for uterine fibroids.

The Cochrane database of systematic reviews, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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