From the Research
Reteplase 10 units is equivalent to 17.4 mg. For practical use, Reteplase is typically supplied in vials containing 10 units (17.4 mg) of lyophilized powder for reconstitution. When administering Reteplase for conditions like acute myocardial infarction, the standard dose is two 10-unit bolus injections given 30 minutes apart. It's essential to note that Reteplase dosing is usually expressed in units rather than milligrams in clinical practice. The unit-to-milligram conversion is provided for reference, but healthcare providers should always follow the unit-based dosing instructions provided with the medication. The relationship between units and milligrams for Reteplase is based on its specific activity and potency as a thrombolytic agent. This conversion factor allows for standardized dosing across different preparations of the drug.
Key points to consider:
- The standard dose of Reteplase for acute myocardial infarction is two 10-unit bolus injections given 30 minutes apart 1, 2, 3.
- Reteplase is effective and well-tolerated in the management of ST-elevated myocardial infarction (STEMI) in various patient populations, including those with diabetes 4.
- The use of Reteplase has been explored in other clinical settings, such as occluded central venous catheters in children with cancer, where it has shown promise as a rapid and effective treatment option 5.
- The safety and efficacy of Reteplase have been evaluated in numerous clinical trials, demonstrating its value as a thrombolytic agent in the management of acute myocardial infarction and other thrombotic disorders 1, 2, 3.