From the Research
Hypertension is a risk factor for chronic venous insufficiency (CVI), as evidenced by the most recent study in 2025, which found that CVI is an independent risk factor for coronary artery disease, even after adjusting for age, hypertension, and dyslipidemia as confounding factors 1. The relationship between hypertension and CVI is complex, with hypertension contributing to CVI development through several mechanisms, including damage to venous valves, endothelial dysfunction, and vascular inflammation. Key points to consider in the management of patients with hypertension and CVI include:
- Monitoring for signs of CVI, such as leg swelling, varicose veins, skin changes, and discomfort
- Managing hypertension through medication, weight control, regular exercise, and reduced sodium intake to reduce the risk of developing or worsening CVI
- Comprehensive management addressing both hypertension and venous insufficiency for optimal outcomes The most recent study 1 provides strong evidence for the association between CVI and coronary artery disease, highlighting the importance of considering CVI as a risk factor for cardiovascular disease. Other studies, such as 2, 3, 4, and 5, provide additional insights into the pathophysiology and management of CVI, but the 2025 study 1 is the most relevant and recent evidence for the relationship between hypertension and CVI. In clinical practice, it is essential to prioritize the management of hypertension and CVI to reduce the risk of morbidity, mortality, and impaired quality of life. By considering the latest evidence and guidelines, healthcare providers can provide optimal care for patients with hypertension and CVI, addressing both conditions comprehensively to achieve the best possible outcomes.