From the Guidelines
Genistein, a compound found in soy products, is the most likely soy derivative to help protect against cannabis-induced myocardial infarction or cerebrovascular accident. To potentially benefit, consume soy foods rich in genistein such as tofu, tempeh, edamame, or soy milk regularly [ 1 ]. Alternatively, genistein supplements are available, typically in doses of 50-100 mg per day, though you should consult a doctor before starting any supplement regimen.
Key Points to Consider
- Genistein works by inhibiting certain enzymes that cannabis activates, which can lead to increased blood pressure and heart rate [ 1 ].
- It may also have antioxidant and anti-inflammatory properties that support cardiovascular health.
- While promising, more research is needed to fully establish genistein's protective effects against cannabis-related cardiovascular risks.
- The safest approach is to avoid or limit cannabis use, especially if you have pre-existing heart conditions [ 1 ].
- Genistein should not be viewed as a license to use cannabis without concern, but rather as a potential added layer of protection for those who choose to use it.
Important Considerations for Cannabis Use
- Cannabis use has a dose-dependent relationship with stroke, and observational data identify that substance use increases the odds of stroke [ 1 ].
- Proposed mechanisms include hemodynamic alterations, platelet activation, electrophysiological effects, vasculopathy, and cardioembolism.
- Effective primary prevention requires population-level approaches, targeting first the largest proportion at risk (i.e., those misusing substances).
From the Research
Soy Derivative and Cardiovascular Protection
- Genistein, a polyphenolic isoflavone compound found in soy or soy-based products, has been associated with reducing the risk of cardiovascular disorders 2, 3, 4.
- The cardioprotective effects of genistein may be attributed to its anti-oxidant, anti-inflammatory, and anti-angiogenic activities 2, 3, 4, 5.
- Genistein has been shown to inhibit the oxidation of LDL, protect endothelial cells from damage by oxidized LDL, and prevent the upregulation of tyrosine-phosphorylated proteins induced by oxidized LDL 5.
Genistein and Neuroprotection
- Genistein has been found to have neuroprotective effects in cortical cells, which may be mediated by its regulation of the anti-apoptotic protein bcl-2 6.
- The neuroprotective effects of genistein may be relevant in preventing disorders such as cerebrovascular accidents.