What is the diagnosis for a patient with diminished arterial pulses, warm to cold skin temperature gradient from proximal to distal, moderate non-pitting edema on the medial border of the left hallux toenail, erythema, and sparse hair growth, with normal venous flow and no varicosities?

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Differential Diagnosis

  • Single most likely diagnosis
    • Peripheral Arterial Disease (PAD): The patient's symptoms, including decreased pulses in the lower extremities (femoral 2/4, popliteal 2/4, dorsalis pedis 1/4, and posterior tibial 1/4), warm to cold skin temperature gradient from proximal to distal, and sparse hair growth, are consistent with PAD. The presence of moderate non-pitting edema, erythema, and digital capillary return of less than three seconds also support this diagnosis.
  • Other Likely diagnoses
    • Atherosclerosis: The patient's symptoms, such as decreased pulses and sparse hair growth, could be related to atherosclerosis, which is a common cause of PAD.
    • Hypertension: Uncontrolled hypertension can lead to vascular damage, which may contribute to the patient's symptoms.
    • Diabetes mellitus: Diabetes is a risk factor for PAD and can cause similar symptoms, including decreased pulses and skin changes.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Acute limb ischemia: Although the patient's symptoms are chronic, it is essential to rule out acute limb ischemia, which is a medical emergency that requires prompt treatment.
    • Embolic event: An embolic event, such as a pulmonary embolism or a cardiac embolism, could cause similar symptoms and requires immediate attention.
    • Vasculitis: Vasculitis, such as giant cell arteritis or Takayasu arteritis, can cause vascular inflammation and damage, leading to similar symptoms.
  • Rare diagnoses
    • Buerger's disease (Thromboangiitis obliterans): This rare disease causes inflammation and clotting of blood vessels, leading to decreased pulses and skin changes.
    • Raynaud's phenomenon: This condition causes vasospasm of blood vessels, leading to decreased pulses and skin changes, particularly in response to cold temperatures or stress.
    • Popliteal artery entrapment syndrome: This rare condition causes compression of the popliteal artery, leading to decreased pulses and skin changes in the affected limb.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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