From the Research
The equivalent dose of nifedipine to felodipine 10mg is approximately 30-40mg of immediate-release nifedipine or 60mg of extended-release nifedipine daily. When switching between these calcium channel blockers, it's essential to consider their different pharmacokinetic profiles. Felodipine is more vascular-selective and has a longer half-life than immediate-release nifedipine, which explains the dosing difference 1. The extended-release formulation of nifedipine is preferred for most clinical situations as it provides more consistent blood levels and reduces side effects like reflex tachycardia.
Some key points to consider when switching between these medications include:
- Monitoring blood pressure closely for the first few days as individual responses may vary
- Being aware that both medications can cause peripheral edema, flushing, and headache, though felodipine may cause less edema due to its higher vascular selectivity 2
- Allowing sufficient time to evaluate whether the alternative medication provides better tolerability if switching due to side effects
It's also important to note that the choice between felodipine and nifedipine should be based on individual patient needs and responses, as well as consideration of their specific pharmacological properties and potential side effects 3.