What is the cause of shin lesions in a patient with inflammatory bowel disease (IBD)?

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Last updated: May 27, 2025View editorial policy

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Differential Diagnosis for Shin Lesions with Inflammatory Bowel Disease

  • Single Most Likely Diagnosis
    • Erythema Nodosum: This is a common skin manifestation of inflammatory bowel disease (IBD), particularly Crohn's disease and ulcerative colitis. It presents as tender, erythematous nodules on the shins, often associated with active disease.
  • Other Likely Diagnoses
    • Pyoderma Gangrenosum: A skin condition characterized by painful ulcers, often on the legs, associated with IBD. It can start as a pustule or nodule that breaks down to form an ulcer.
    • Psoriasis: Although more commonly associated with psoriatic arthritis, psoriasis can also be linked to IBD, and skin lesions can appear on the shins among other areas.
    • Perianal or Peristomal Pyoderma Gangrenosum with distant lesions: Though typically found around the anus or stoma sites, in rare cases, lesions can appear on the shins.
  • Do Not Miss Diagnoses
    • Vasculitis (e.g., Granulomatosis with Polyangiitis): Although less common, vasculitis can present with skin lesions and is associated with a range of systemic symptoms, including those affecting the gastrointestinal tract. Missing this diagnosis could lead to severe complications.
    • Deep Vein Thrombosis (DVT): In patients with IBD, especially those with active disease or on certain medications, there's an increased risk of DVT, which could present with leg swelling and pain, mimicking shin lesions.
  • Rare Diagnoses
    • Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis): Characterized by fever, neutrophilia, and tender, erythematous skin lesions, Sweet Syndrome can be associated with IBD but is relatively rare.
    • Metastatic Crohn's Disease: A rare condition where granulomatous lesions similar to those found in Crohn's disease appear in the skin, distant from the gastrointestinal tract, potentially on the shins.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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