From the Research
After reconstitution, famotidine suspension should be stored in the refrigerator at 2-8°C (36-46°F) and used within 20 days, as the concentration of famotidine remained above 90% of original concentration for 20 days at 4 degrees C 1. The storage considerations for famotidine suspension are crucial to maintain its stability and effectiveness.
- Refrigeration is necessary to maintain the stability and effectiveness of the reconstituted suspension.
- The 20-day limit helps ensure the medication remains potent and free from potential microbial growth.
- Protecting the suspension from light is also important to prevent degradation of the active ingredient. Some studies have shown that famotidine is stable in certain solutions, such as dextrose 5% injection and NaCl 0.9% injection, when stored in polyvinyl chloride bags at 4 degrees C for 14 days or when frozen for 28 days and then refrigerated for 14 days 2, 3. However, these studies are not directly applicable to the storage of famotidine suspension after reconstitution. The most relevant study found that the concentration of famotidine remained above 90% of original concentration for 20 days at 4 degrees C 1. Therefore, it is recommended to store the reconstituted suspension in the refrigerator and use it within 20 days. Always check the expiration date on the original packaging and do not use the medication if it has expired, even if it was reconstituted within the last 20 days. If the suspension develops an unusual odor, color, or appearance, do not use it and consult a pharmacist.