From the Research
There is no known significant interaction between nattokinase and angelica dahurica, but caution is advised when combining them due to their potential blood-thinning effects. Nattokinase is known to have anticoagulant properties, while angelica dahurica contains coumarins that may also affect blood clotting 1. If you're considering taking these supplements together, especially if you're on blood thinners or have a bleeding disorder:
- Start with low doses of each supplement.
- Monitor for any signs of increased bruising or bleeding.
- Consult your healthcare provider before combining them, particularly if you have any underlying health conditions or are taking medications. The potential for interaction stems from their shared effects on blood coagulation pathways. Nattokinase works by breaking down fibrin, while angelica dahurica's coumarins may interfere with vitamin K-dependent clotting factors. While direct studies on their interaction are limited, this theoretical overlap in effects warrants careful consideration, as seen in studies on concomitant use of anticoagulants and antiplatelets, which have shown an increased risk of bleeding 2, 3, 4, 5.
However, it's essential to note that the provided evidence does not directly address the interaction between nattokinase and angelica dahurica. The studies cited focus on the concomitant use of anticoagulants, antiplatelets, and other medications, which may not be directly applicable to the interaction between these two supplements. Nevertheless, as a precautionary measure, it's crucial to exercise caution when combining any substances that may affect blood coagulation, and consulting a healthcare provider is always recommended.