From the Research
The most popular compounded medications for scars in the USA include silicone-based formulations, as evidenced by the latest study in 2020 1, which supports their efficacy in scar management.
Key Compounded Medications for Scars
- Silicone-based compounds, such as dimethicone or cyclopentasiloxane, applied topically to flatten and soften raised scars
- Corticosteroid compounds, typically containing triamcinolone acetonide, for injection into hypertrophic or keloid scars
- Combination products, including the "triple cream" with triamcinolone, 5-fluorouracil, and tretinoin, addressing multiple aspects of scar formation
- Onion extract (quercetin) with allantoin, possessing anti-inflammatory properties
Mechanism of Action and Treatment
These medications work by modulating collagen production, reducing inflammation, and improving scar hydration. The treatment duration varies from weeks to months, depending on scar type and severity, with best results seen when treatment begins early in scar formation. Application frequency ranges from twice daily for topical preparations to monthly injections for corticosteroids.
Side Effects and Evaluation
Side effects may include skin irritation, hypopigmentation, or skin atrophy with prolonged steroid use, so periodic evaluation by a healthcare provider is recommended. The latest systematic review and meta-analysis 1 supports the efficacy of topical silicone gel in scar management, making it a recommended treatment option. Additionally, a study from 2020 2 highlights the use of silicone sheets and new gels to treat hypertrophic scars and keloids, further emphasizing the importance of silicone-based formulations in scar treatment.