From the Research
The most popular topical compounded medications for scars in the USA typically include silicone-based formulations, corticosteroids, and combination products, with silicone gel and tretinoin cream being effective in preventing hypertrophic scars and keloids, as shown in a study published in 2023 1. The use of these compounds is based on their ability to modulate collagen production, reduce inflammation, improve hydration, and promote proper wound healing.
- Silicone-based compounds, such as silicone gel with vitamin E (5-10%), are widely used and applied twice daily for 3-6 months to improve scar appearance.
- Triamcinolone acetonide (0.1-0.5%) is a common corticosteroid used for hypertrophic and keloid scars, applied thinly once or twice daily for 2-4 weeks.
- Combination compounds often include multiple active ingredients, such as triamcinolone (0.1%), 5-fluorouracil (5%), and silicone in a single formulation for enhanced efficacy.
- Other popular compounds include onion extract (quercetin) with allantoin, tranexamic acid (2-5%) for pigmented scars, and vitamin C (5-20%) with vitamin E for their antioxidant properties. A systematic review published in 2020 found that silicone gel products are an effective noninvasive treatment to prevent formation of pathologic scars and improve mature scars 2. For best results, treatment should begin early in scar formation, and patients should protect treated areas from sun exposure to prevent hyperpigmentation, as suggested by a study published in 2018 3. Most of these compounds require a prescription and are prepared by compounding pharmacies according to dermatologist specifications for individual patient needs. It is essential to note that while there is evidence supporting the use of these topical compounds, further high-quality studies are needed to elucidate the long-term effectiveness of these therapies, as highlighted by a study published in 2014 4.