Does genistein from soy have the same effect as genistein from Sophora japonica?

From the Guidelines

Genistein from soy and genistein from Sophora japonica have similar but not identical effects, with soy-derived genistein being more bioavailable and potent due to its direct form, whereas genistein from Sophora japonica may require conversion to become active 1. The difference in bioavailability and potency between genistein from soy and Sophora japonica is crucial when considering their potential health benefits, such as antioxidant effects, potential cancer prevention, and relief of menopausal symptoms.

• Genistein is a phytoestrogen with estrogenic properties, and its effects on the body can vary depending on the source and form of consumption.
• The conversion process of genistin to genistein in the body can reduce its overall effectiveness compared to direct genistein consumption from soy products 1.
• Typical daily intake from soy foods ranges from 20-50 mg of isoflavones, and supplements often provide 50-100 mg per day, but it is essential to consult a healthcare provider before starting any supplement regimen, as these compounds can interact with certain medications and may not be suitable for everyone.
• The American Heart Association has noted that soy isoflavones, including genistein, have strong biological properties, causing arterial vasodilation, lowering serum cholesterol, and inhibiting atherosclerosis in post-menopausal monkeys 1.
• The exact dosage and effectiveness of genistein from Sophora japonica can vary, and more research is needed to fully understand its effects on human health.
• However, based on the available evidence, soy products rich in genistein may be a more reliable and studied source of this phytoestrogen, and their consumption may be associated with improved cardiovascular health and other potential benefits 1.

From the Research

Comparison of Genistein from Soy and Sophora japonica

• The effect of genistein from soy and Sophora japonica on anti-osteoporosis has been studied, with results indicating that genistein from both sources has a similar beneficial effect on anti-osteoporosis 2.
• A study on the pharmacological effects of genistein from Sophora japonica found that it prevented osteoporosis significantly at a dosage of 4.5 or 9 mg/kg, similar to the effects of soybean genistein 2.
• The chemical structure of genistein from Sophora japonica was found to be identical to that of genistein from soybean, suggesting that the source of genistein may not affect its biological activity 2.
• Other studies have focused on the antioxidant, anti-inflammatory, and anticancer effects of genistein from soy, but have not directly compared these effects to genistein from Sophora japonica 3, 4.
• The levels of genistein in soybeans and soybean products have been quantified, with fermented soybean products found to have higher levels of genistein than non-fermented products 5.
• Sophora japonica seeds have been found to contain genistin, a compound that has been shown to have estrogenic proliferative effects and may have anti-osteoporotic activity 6.