From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
The most popular compounded dermatology medications in the USA include combination formulations containing tretinoin, niacinamide, hydroquinone, and corticosteroids, as well as acne preparations combining tretinoin with antibiotics like clindamycin or erythromycin, and anesthetics like BLT cream for pre-procedure numbing. These compounded medications are prescribed when commercially available products don't meet specific patient needs, allowing for customized concentrations, combinations of active ingredients, and exclusion of allergens or irritants 1. Some of the key ingredients used in these compounded medications include:
- Tretinoin, which is often combined with niacinamide, hydroquinone, and corticosteroids to treat melasma and hyperpigmentation disorders
- Clindamycin and erythromycin, which are commonly used in acne preparations, sometimes with added niacinamide or azelaic acid
- Tacrolimus, which is used in compounded formulations for inflammatory conditions, often with various anti-inflammatory agents
- Benzocaine, lidocaine, and tetracaine, which are used in BLT cream for pre-procedure numbing 2, 3. It's worth noting that while these compounded medications can be effective, they are not FDA-approved as combinations and may not be covered by insurance, potentially resulting in higher out-of-pocket costs for patients 1.