From the Research
Yes, there are multiple types of palmar fibromatosis, with the most common being Dupuytren's contracture, which is a benign proliferation of fibroblasts and myofibroblasts, as described in a recent review 1.
Types of Palmar Fibromatosis
- Dupuytren's contracture: causes nodules and cords in the palm that can lead to finger contractures, especially affecting the ring and little fingers
- Ledderhose disease (plantar fibromatosis): affects the feet
- Peyronie's disease: affects the penis
- Knuckle pads (Garrod's nodes)
Pathophysiology and Treatment
These conditions share a common pathophysiology involving abnormal fibroblast proliferation and collagen deposition in the palmar fascia. Treatment options vary by severity and include:
- Observation for mild cases
- Needle aponeurotomy (percutaneous needle fasciotomy)
- Collagenase injections (Xiaflex)
- Surgical fasciectomy for more severe contractures Physical therapy and splinting may help maintain range of motion after treatment.
Risk Factors and Prognosis
These conditions are often associated with genetic predisposition, and risk factors include diabetes, smoking, alcohol consumption, certain medications, and manual labor, as noted in a study on palmar-plantar fibromatosis in children and preadolescents 2. Early intervention is important as these conditions tend to progress over time. A review of musculoskeletal fibromatoses highlights the importance of radiologic-pathologic correlation in diagnosis and treatment 3.