From the Guidelines
Celebrex (celecoxib) should be dosed at 150 mg for ankylosing spondylitis, with the option to increase to 300 mg based on clinical response, as recommended by the most recent and highest quality study 1. The dosing of celebrex can vary depending on the condition being treated, but for ankylosing spondylitis, the recommended dose is clearly stated in the most recent study 1. Some key points to consider when dosing celebrex include:
- Taking the medication with food to improve absorption and reduce stomach irritation
- Adjusting doses for elderly patients, those with liver impairment, or patients weighing less than 50 kg, typically starting at the lowest effective dose
- Being aware of the potential cardiovascular risks associated with celebrex, especially at higher doses or with prolonged use, and using the lowest effective dose for the shortest duration necessary 1. It's also important to note that celebrex works by selectively inhibiting COX-2 enzymes, reducing inflammation and pain while potentially causing fewer gastrointestinal side effects than traditional NSAIDs. However, the primary consideration should be the most recent and highest quality study, which recommends a dose of 150 mg for ankylosing spondylitis, with the option to increase to 300 mg based on clinical response 1.
From the FDA Drug Label
- 1 General Dosing Instructions Carefully consider the potential benefits and risks of celecoxib capsules and other treatment options before deciding to use celecoxib capsules. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5)].
- 2 Osteoarthritis For OA, the dosage is 200 mg per day administered as a single dose or as 100 mg twice daily. 2.3 Rheumatoid Arthritis For RA, the dosage is 100 mg to 200 mg twice daily.
- 4 Juvenile Rheumatoid Arthritis For JRA, the dosage for pediatric patients (age 2 years and older) is based on weight. For patients ≥10 kg to ≤25 kg the recommended dose is 50 mg twice daily. For patients >25 kg the recommended dose is 100 mg twice daily.
- 5 Ankylosing Spondylitis For AS, the dosage of celecoxib capsules are 200 mg daily in single (once per day) or divided (twice per day) doses.
- 6 Management of Acute Pain and Treatment of Primary Dysmenorrhea For management of Acute Pain and Treatment of Primary Dysmenorrhea, the dosage is 400 mg initially, followed by an additional 200 mg dose if needed on the first day.
The dosing for celebrex is as follows:
- Osteoarthritis (OA): 200 mg per day administered as a single dose or as 100 mg twice daily.
- Rheumatoid Arthritis (RA): 100 mg to 200 mg twice daily.
- Juvenile Rheumatoid Arthritis (JRA):
- For patients ≥10 kg to ≤25 kg: 50 mg twice daily.
- For patients >25 kg: 100 mg twice daily.
- Ankylosing Spondylitis (AS): 200 mg daily in single or divided doses.
- Acute Pain and Primary Dysmenorrhea: 400 mg initially, followed by an additional 200 mg dose if needed on the first day, then 200 mg twice daily as needed 2.
From the Research
Dosing Information for Celebrex
- The recommended dosages of Celebrex are 200 or 400 mg/day 3.
- Celebrex is indicated in the EU for the symptomatic treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in adults, and the recommended dosages are effective for these conditions 3.
- In the management of acute pain in adults, Celebrex remains an effective and useful alternative to nonselective NSAIDs, and should be used at the lowest effective dose for the shortest possible duration 4.
Considerations for Dosing
- The potential GI, CV and renal risks of Celebrex must be weighed against the potential benefits in each individual 3, 4.
- Celebrex should be used at the lowest effective dosage for the shortest possible duration after a careful evaluation of the GI, cardiovascular and renal risks of the individual patient 3.
- Concomitant administration of Celebrex with low-dose cardioprotective aspirin may negate the GI-sparing advantages of Celebrex over NSAIDs 3.